Identification of A gene responsible for familial wolff-parkinson-white syndrome
Identifieur interne : 003316 ( Main/Exploration ); précédent : 003315; suivant : 003317Identification of A gene responsible for familial wolff-parkinson-white syndrome
Auteurs : Michael H. Gollob [États-Unis] ; Martin S. Green [Canada] ; Anthony S.-L. Tang [Canada] ; Tanya Gollob [États-Unis] ; Akihiko Karibe [États-Unis] ; Al-Sayegh Hassan [Canada] ; Ferhaan Ahmad [États-Unis] ; Ryan Lozado [États-Unis] ; Gopi Shah [États-Unis] ; Lameh Fananapazir [Canada, États-Unis] ; Linda L. Bachinski [États-Unis] ; Robert Roberts [États-Unis]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2001.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
Background The Wolff-Parkinson-White syndrome, with a prevalence in Western countries of 1.5 to 3.1 per 1000 persons, causes considerable morbidity and may cause sudden death. We identified two families in which the Wolff-Parkinson-White syndrome segregated as an autosomal dominant disorder. Methods We studied 70 members of the two families (57 in Family 1 and 13 in Family 2). The subjects underwent 12-lead electrocardiography and two-dimensional echocardiography. Genotyping mapped the gene responsible to 7q34-q36, a locus previously identified to be responsible for an inherited form of Wolff-Parkinson-White syndrome. Candidate genes were identified, sequenced, and analyzed in normal and affected family members to identify the disease-causing gene. Results A total of 31 members (23 from Family 1 and 8 from Family 2) had the Wolff-Parkinson-White syndrome. Affected members of both families had ventricular preexcitation with conduction abnormalities and cardiac hypertrophy. The maximal combined two-point lod score was 9.82 at a distance of 5 cM from marker D7S636, which confirmed the linkage of the gene in both families to 7q34-q36. Haplotype analysis indicated that there were no alleles in common in the two families at this locus, suggesting that the two families do not have a common founder. We identified a missense mutation in the gene that encodes the y2 regulatory subunit of AMP-activated protein kinase (PRKAG2). The mutation results in the substitution of glutamine for arginine at residue 302 in the protein. Conclusions The identification of this genetic defect has important implications for elucidating the pathogenesis of ventricular preexcitation. Further understanding of how this molecular defect leads to supraventricular arrhythmias could influence the development of specific therapies for other forms of supraventricular arrhythmia.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Identification of A gene responsible for familial wolff-parkinson-white syndrome</title><author><name sortKey="Gollob, Michael H" sort="Gollob, Michael H" uniqKey="Gollob M" first="Michael H." last="Gollob">Michael H. Gollob</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Green, Martin S" sort="Green, Martin S" uniqKey="Green M" first="Martin S." last="Green">Martin S. Green</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Anthony S L" sort="Tang, Anthony S L" uniqKey="Tang A" first="Anthony S.-L." last="Tang">Anthony S.-L. Tang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation></author><author><name sortKey="Gollob, Tanya" sort="Gollob, Tanya" uniqKey="Gollob T" first="Tanya" last="Gollob">Tanya Gollob</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Karibe, Akihiko" sort="Karibe, Akihiko" uniqKey="Karibe A" first="Akihiko" last="Karibe">Akihiko Karibe</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Hassan, Al Sayegh" sort="Hassan, Al Sayegh" uniqKey="Hassan A" first="Al-Sayegh" last="Hassan">Al-Sayegh Hassan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Ferhaan" sort="Ahmad, Ferhaan" uniqKey="Ahmad F" first="Ferhaan" last="Ahmad">Ferhaan Ahmad</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Lozado, Ryan" sort="Lozado, Ryan" uniqKey="Lozado R" first="Ryan" last="Lozado">Ryan Lozado</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Shah, Gopi" sort="Shah, Gopi" uniqKey="Shah G" first="Gopi" last="Shah">Gopi Shah</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Fananapazir, Lameh" sort="Fananapazir, Lameh" uniqKey="Fananapazir L" first="Lameh" last="Fananapazir">Lameh Fananapazir</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Inherited Heart Disease Section, National Heart</s1><s2>Lung</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lung</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Blood Institute, National Institutes of Health</s1><s2>Bethesda, Md</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Md</wicri:noRegion></affiliation></author><author><name sortKey="Bachinski, Linda L" sort="Bachinski, Linda L" uniqKey="Bachinski L" first="Linda L." last="Bachinski">Linda L. 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Gollob</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Green, Martin S" sort="Green, Martin S" uniqKey="Green M" first="Martin S." last="Green">Martin S. Green</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Anthony S L" sort="Tang, Anthony S L" uniqKey="Tang A" first="Anthony S.-L." last="Tang">Anthony S.-L. Tang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation></author><author><name sortKey="Gollob, Tanya" sort="Gollob, Tanya" uniqKey="Gollob T" first="Tanya" last="Gollob">Tanya Gollob</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Karibe, Akihiko" sort="Karibe, Akihiko" uniqKey="Karibe A" first="Akihiko" last="Karibe">Akihiko Karibe</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Hassan, Al Sayegh" sort="Hassan, Al Sayegh" uniqKey="Hassan A" first="Al-Sayegh" last="Hassan">Al-Sayegh Hassan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ahmad, Ferhaan" sort="Ahmad, Ferhaan" uniqKey="Ahmad F" first="Ferhaan" last="Ahmad">Ferhaan Ahmad</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Lozado, Ryan" sort="Lozado, Ryan" uniqKey="Lozado R" first="Ryan" last="Lozado">Ryan Lozado</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Shah, Gopi" sort="Shah, Gopi" uniqKey="Shah G" first="Gopi" last="Shah">Gopi Shah</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Fananapazir, Lameh" sort="Fananapazir, Lameh" uniqKey="Fananapazir L" first="Lameh" last="Fananapazir">Lameh Fananapazir</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University of Ottawa Heart Institute</s1><s2>Ottawa, Ont</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>University of Ottawa Heart Institute</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Inherited Heart Disease Section, National Heart</s1><s2>Lung</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Lung</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Blood Institute, National Institutes of Health</s1><s2>Bethesda, Md</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, Md</wicri:noRegion></affiliation></author><author><name sortKey="Bachinski, Linda L" sort="Bachinski, Linda L" uniqKey="Bachinski L" first="Linda L." last="Bachinski">Linda L. Bachinski</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Roberts, Robert" sort="Roberts, Robert" uniqKey="Roberts R" first="Robert" last="Roberts">Robert Roberts</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Cardiology, Baylor College of Medicine</s1><s2>Houston</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome</term><term>Clinical biology</term><term>Etiology</term><term>Family study</term><term>Genetic identification</term><term>Human</term><term>Morbidity</term><term>Prevalence</term><term>Wolff Parkinson White syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Wolff Parkinson White syndrome</term><term>Etude familiale</term><term>Prévalence</term><term>Identification génétique</term><term>Chromosome</term><term>Etiologie</term><term>Biologie clinique</term><term>Morbidité</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background The Wolff-Parkinson-White syndrome, with a prevalence in Western countries of 1.5 to 3.1 per 1000 persons, causes considerable morbidity and may cause sudden death. We identified two families in which the Wolff-Parkinson-White syndrome segregated as an autosomal dominant disorder. Methods We studied 70 members of the two families (57 in Family 1 and 13 in Family 2). The subjects underwent 12-lead electrocardiography and two-dimensional echocardiography. Genotyping mapped the gene responsible to 7q34-q36, a locus previously identified to be responsible for an inherited form of Wolff-Parkinson-White syndrome. Candidate genes were identified, sequenced, and analyzed in normal and affected family members to identify the disease-causing gene. Results A total of 31 members (23 from Family 1 and 8 from Family 2) had the Wolff-Parkinson-White syndrome. Affected members of both families had ventricular preexcitation with conduction abnormalities and cardiac hypertrophy. The maximal combined two-point lod score was 9.82 at a distance of 5 cM from marker D7S636, which confirmed the linkage of the gene in both families to 7q34-q36. Haplotype analysis indicated that there were no alleles in common in the two families at this locus, suggesting that the two families do not have a common founder. We identified a missense mutation in the gene that encodes the y2 regulatory subunit of AMP-activated protein kinase (PRKAG2). The mutation results in the substitution of glutamine for arginine at residue 302 in the protein. Conclusions The identification of this genetic defect has important implications for elucidating the pathogenesis of ventricular preexcitation. Further understanding of how this molecular defect leads to supraventricular arrhythmias could influence the development of specific therapies for other forms of supraventricular arrhythmia.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Gollob, Michael H" sort="Gollob, Michael H" uniqKey="Gollob M" first="Michael H." last="Gollob">Michael H. Gollob</name></region><name sortKey="Ahmad, Ferhaan" sort="Ahmad, Ferhaan" uniqKey="Ahmad F" first="Ferhaan" last="Ahmad">Ferhaan Ahmad</name><name sortKey="Bachinski, Linda L" sort="Bachinski, Linda L" uniqKey="Bachinski L" first="Linda L." last="Bachinski">Linda L. Bachinski</name><name sortKey="Fananapazir, Lameh" sort="Fananapazir, Lameh" uniqKey="Fananapazir L" first="Lameh" last="Fananapazir">Lameh Fananapazir</name><name sortKey="Fananapazir, Lameh" sort="Fananapazir, Lameh" uniqKey="Fananapazir L" first="Lameh" last="Fananapazir">Lameh Fananapazir</name><name sortKey="Gollob, Tanya" sort="Gollob, Tanya" uniqKey="Gollob T" first="Tanya" last="Gollob">Tanya Gollob</name><name sortKey="Karibe, Akihiko" sort="Karibe, Akihiko" uniqKey="Karibe A" first="Akihiko" last="Karibe">Akihiko Karibe</name><name sortKey="Lozado, Ryan" sort="Lozado, Ryan" uniqKey="Lozado R" first="Ryan" last="Lozado">Ryan Lozado</name><name sortKey="Roberts, Robert" sort="Roberts, Robert" uniqKey="Roberts R" first="Robert" last="Roberts">Robert Roberts</name><name sortKey="Shah, Gopi" sort="Shah, Gopi" uniqKey="Shah G" first="Gopi" last="Shah">Gopi Shah</name></country><country name="Canada"><noRegion><name sortKey="Green, Martin S" sort="Green, Martin S" uniqKey="Green M" first="Martin S." last="Green">Martin S. Green</name></noRegion><name sortKey="Fananapazir, Lameh" sort="Fananapazir, Lameh" uniqKey="Fananapazir L" first="Lameh" last="Fananapazir">Lameh Fananapazir</name><name sortKey="Hassan, Al Sayegh" sort="Hassan, Al Sayegh" uniqKey="Hassan A" first="Al-Sayegh" last="Hassan">Al-Sayegh Hassan</name><name sortKey="Tang, Anthony S L" sort="Tang, Anthony S L" uniqKey="Tang A" first="Anthony S.-L." last="Tang">Anthony S.-L. Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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